Tropoflavin 7,8-Dihydroxyflavone Supplement
7,8-DHF also known as 7,8-dihydroxyflavone,It has been found to act as a potent and selective small-molecule agonist of the tropomyosin receptor kinase B (TrkB) (Kd ≈ 320 nM), the main signaling receptor of the neurotrophinbrain-derived neurotrophic factor (BDNF)
Technical Data for trans-ISRIB
| M. Wt | 451.34 |
| Formula | C22H24Cl2N2O4 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1597403-47-8 |
| PubChem ID | 1011240 |
| InChI Key | HJGMCDHQPXTGAV-UHFFFAOYSA-N |
| Smiles | O=C(COC1=CC=C(Cl)C=C1)N[C@@H]2CC[C@@H](NC(COC3=CC=C(Cl)C=C3)=O)CC2 |
Tropoflavin is both orally bioavailable and able to penetrate the blood–brain barrier. A prodrug of tropoflavin with greatly improved potency and pharmacokinetics, R13 (and, formerly, R7), is under development for the treatment of Alzheimer’s disease. Displays memory enhancement in hippocampus-dependent spatial and fear-associated learning in rodents. trans-ISRIB promotes survival of pluripotent stem cells in culture when used in combination with Chroman-1 (Cat. No. 7163), emricasan, and polyamines, a combination known as CEPT. When used as part of the CEPT cocktail, trans-ISRIB improves survival of differentiated cells following cryopreservation. Brain penetrant.