Eutropoflavin (4′-Dimethylamino-7,8-dihydroxyflavone)

is a synthetic flavone and selective small-molecule agonist of TrkB, the main receptor of brain-derived neurotrophic factor (BDNF), which was derived from structural modification of tropoflavin (7,8-DHF)

Technical Data for 4′-Dimethylamino-7,8-dihydroxyflavone

Relative to tropoflavin, eutropoflavin possesses higher agonistic activity at TrkB, is significantly more potent than tropoflavin both in vitro and in vivo, and has a longer duration of action (peaking at 4 hours and “partially decaying” at 8~16 hours in rodents)